Charlotte’s web (cannabis)

Charlotte’s Web is a high- cannabidiol (CBD), low- tetrahydrocannabinol (THC) Cannabis extract marketed as a dietary supplement under federal law of the United States. [1] [2] [3] It is produced by the Stanley brothers in Colorado. It does not induce the psychoactive ” high ” typically associated with recreational marijuana strains that are high in THC. [4] In September 2014, the Stanleys announced that they would ensure that the product is less than 0.3% THC. [5]

Charlotte’s Web is named after Charlotte Figi, born October 18, 2006 (age 11) , whose story has been described as “the girl who is changing medical marijuana laws across America.” [6] Her relatives say she Experienced physicians and a reduction of her epileptic seizures Brought on by Dravet syndrome after-her first dose of medical marijuana at five years of age. Her usage of Charlotte’s Web was first featured in the 2013 CNN documentary “Weed”. Media coverage increased demand for CBD, which has been used to treat epilepsyin toddlers and children. It was originally called “Hippie’s Disappointment” as it was a strain that had high CBD instead of THC. [7]

While anecdotal reports have sparked interest in cannabinoids , [8] there is not enough evidence to draw conclusions about their safety or efficacy. [8] [9] Physicians worry that some parents are willing to try, and that they may be disappointed. They are “alarmed by parallels to past miracle-cure manias later proved false …” and “… wary of the heightened placebo effect in treating children, when reports of progress depend on the view of parents.” [10]

Medical uses


There is little evidence about the safety or efficacy of cannabinoids in the treatment of epilepsy. [8] [11] A 2014 Cochrane review did not find enough evidence to draw conclusions about its use. [12] A 2014 review by the American Academy of Neurology, which is “Data is insufficient to support or refute the efficacy of cannabinoids for reducing seizure frequency.” [13]

The Cochrane Review suggests that you may have problems with EEG-video monitoring to confirm diagnosis, and are not eligible for such and such surgery and neurostimulation. [14] A second review of four placebo-controlled trials of cannabadiol, including 48 people with a disease that was not manageable by other means. Three out of four trials of seizures, but no comparison with placebo was possible in the trials. The drugs were well tolerated. [15]A third review found that no reliable conclusions about the effect of cannabis on epilepsy could be drawn from the poor quality of data available, but further research may be warranted because of the good safety profile observed in small clinical trials. [16]

A 2017 study found cannabidiol reduced seizures convulsive seizures. [17]


Due to the anecdotal nature of the health claims being made.

A position statement by the American Epilepsy Society states:

The recent anecdotal reports of positive effects of marijuana cannabidiol derivative for some individuals with treatment-resistant epilepsy give reason for hope. However, we must remember that these are only anecdotal reports, and robust scientific evidence for the use of marijuana is lacking … at present, the epilepsy does not know if marijuana is safe and effective treatment, nor do they know the long effects that marijuana will have on learning, memory and behavior, especially in infants and young children. [18]

Cannabis-derived products are not mentioned in the National Institute for Health and Care Excellence epilepsy treatment guidelines. [19]


Cannabis oil

Charlotte’s Web was developed in 2011 by the Stanley brothers (Joel, Jesse, Jon, Jordan, Josh Jared and [20] ) through crossbreeding a strain of marijuana with industrial hemp. [21] This process is a phenomenon with less tetrahydrocannabinol (THC) and more cannabidiol (CBD) than typical types of marijuana. [22] The variety shows potential for medical use, especially for those who do not wish to experience the typical high of recreational marijuana use. [23] As it is so low in THC, the variety was originally called “Hippie’s Disappointment”, [24] and also has been labeled “boring”. [25]It is a less profitable plant [26] with “close to no value to traditional marijuana consumers.” [27]

The Stanley brothers grow the plants at their farm and greenhouses. A CBD rich oil is extracted from the harvested plants and concentrated by rotary evaporation . [28] To make it easier to perform clinical trials , they are planning to move the Charlotte’s Web part of their operation to Uruguay . By doing so, they will also be able to import it into any US state as hemp . [2] [3]

The Realm of Caring Foundation (RoC), [1] has 501 (c) (3) nonprofit organization , [29] was set up by the Stanley brothers to help patients “who can not afford the treatment.” [24] They also started “Stanley Brothers Social Enterprises, Inc.”, [3] [30] [31] which has registered the trademark “Charlotte’s Web Hemp Products”. [32] Some products are marketed by CW Hemp (formerly CW Botanicals). [33]

Society and culture

Legal status

With the main ingredient being classified as “industrial hemp”, (Farm Bill) Charlotte’s Web Oil and other CBD products are legal in all 50 states; (as long as the THC content is <.03%) as they are dietary supplements. quote needed ]

The publicity associated with Charlotte’s Web has inspired a number of legislative bills, some of which are in the planning stages, and others which have been proposed or actually passed. Children, as “uniquely powerful advocates for medicinal potency across the country,” [34] have inspired the movement to legalize medicinal marijuana, “a movement which has a face like Charlotte’s-and it’s a young one that’s hard to ignore.” Lawmakers across the country are pushing legislation to legalize marijuana as a treatment for children with epilepsy. ” [35]

Colorado law permits the use of medical conditions for cancer , glaucoma , HIV / AIDS , muscle spasm, seizures , severe pain , severe nausea and dramatic weight loss , and muscle atrophy. [22] The publicity surrounding anecdotal reports of successful treatment of intractable epilepsy with cannabinoids is likely to lead to a surge in interest. [8]

In 2013, the parents of a two-year-old with controversy confronted New Jersey governor Chris Christie , who signed a bill for access to medical marijuana [27] in a controversial dubbed “pot for tots”. [27] [36] [37]

In 2014, legislative proposals in Utah, [38] [39] Arizona, [40] New York, [41] Washington state, [27] Minnesota, [42] and Florida [43] [44] were considered, where “even Someone is now going to make an exception for marijuana extract for medical treatment. [4]

In Utah, Rep. Gage Froerer, R-Huntsville, said in October 2013: “Nothing in federal or state law prohibits the use of hemp products.” [28] He pledged to consult the Utah Substance Abuse Authority, saying: “We need to take a strong look at this and make sure that we have a legislature and we really understand what it is and what it’s not.” [45] In November 2013, he said he would address “three components in sponsoring legislation: access, quality control and research.” He said the Utah Department of Health would probably be involved in quality-control efforts … ” [46]Annette Maughan, President of the Epilepsy Association of Utah, said: “The current law does not preclude its use but it does not allow for its use. [45] On March 21, 2014, Gary Herbert , the governor of Utah, signed a bill giving “access to marijuana extract for treating epilepsy.” [40] The state bill, HB0105, allows the importation of Charlotte’s Web extract across state lines from Colorado to Utah, and covers only use for intractable epilepsy with the consent of a neurologist. [38] [39] Also on March 21, 2014, an Arizona court found “that Arizona’s medical marijuana law permits consumption of the plant in extract form.”

On March 20, 2014, the Florida House of Representatives Budget Committee passed the “so-called Charlotte’s Web measure (CS / HB 843)” [44] designed to limit prosecutors’ ability to prosecute those in possession of low THC / high CBD marijuana (“0.5 percent or less of tetrahydrocannabinol and more than 15 percent of cannabidiol”) used for treating seizures. The law took effect July 1, 2014. [47] [48] Since then, Florida legislators have passed a bill with bipartisan support legalizing the use of Charlotte’s Web, [49] and Governor Rick Scott signed the “Compassionate Medical Cannabis Act of 2014”. “(SB 1030) [43] [50]in law on June 6, 2014. The law is also referred to as “Charlotte’s Web” law. [51] [52] The law specifies the number of distribution centers, which provides various types of nurseries, [53] and provides funding for research. [43]

  • Federal legislation was introduced in 2014 (US 113th Congress 2013-2014) but was never brought to a vote and died in committee. [54] [55] [56] [57]
  • Rep. Perry, Scott (R-PA-4) introduced to the US 114th Congress (2015-2016) HR1635 – Charlotte’s Web Access Medical Act of 2015 [58] with 62 bipartisan co-sponsors. [59] The House Committee on Energy and Commerce , House Committee on the Judiciary , Subcommittee on Health and the United States House Judiciary Subcommittee on Crime, Terrorism , Homeland Security and Investigations .
  • The Therapeutic Hemp Medical Access Act of 2015 (Senate 1333) was introduced with 11 co-sponsors to amend the Controlled Substances Act to exclude cannabidiol and cannabidiol-rich plants from the definition of marijuana. It was referred to the Committee on the Judiciary. [60]

On October 31, 2017, the FDA sent out letters to four CBD marketers, including Stanley Brothers Social Enterprises, LLC (d / b / a CW Hemp), the producer of Charlotte’s Web. They were warned “against making medical claims about cannabidiol (CBD).” The agency also took issue with marketing CBD products as dietary supplements. [61]

Reactions to CBD-only laws

The federal Schedule 1 drug classification [62] broad scientific research on cannabis. However, in late 2015, the United States Drug Enforcement Administration (DEA) makes certain regulatory requirements by the Controlled Substances Act (CSA) for those who are conducting FDA-approved clinical trials on cannabidiol (CBD). These modifications will streamline the research process regarding CBD ‘s possible medicinal value and help foster ongoing scientific studies. [63]

But the Marijuana Policy Project has expressed frustration over the fact that many legislative efforts have been made to address the issue of THC, high CBD medical marijuana products. They believe that such legislation is too restrictive and ignores the claims of THC, leaving “behind 98% of the individuals who can benefit from it.” [64] Referring to the “Charlotte’s Web Medical Hemp Act of 2014,” an editorial in Ladybud Magazine Expressed concern que la law “leaves Thousands of patients out in the cold without safe, legal access to medical marijuana. It aussi ignore science That Seems to indicate that the whole plant is optimal. ” [65]


Charlotte’s Web is named after an American girl, Charlotte Figi. She developed Dravet syndrome (also known as severe myoclonic epilepsy of infancy or SMEI) as a baby. By age three, Figi was severely disabled and having 300 grand mal seizures at week despite treatment. [22] [66] Her parents learned about another child with Dravet Syndrome, who had been using a different type of medical marijuana since June 2011, and decided to try marijuana. [67]Her parents and doctors said that she improved immediately. She now follows a regular rule that uses a solution of the high-CBD marijuana extract in olive oil . She is given the oil under her tongue or in her food. [22] [68]Her parents said in 2013 that her epilepsy had improved so much that she was able to do so in the past. [22] [69]

The type now named After the first type was tried. As their original supply, a type called R4 that is also high in CBD and low in THC, they were running out, they contacted the Stanley Brothers. From the Stanleys’ stock, they have the high-CBD thing that has been renamed to Charlotte’s Web. [22]

Charlotte’s story has been featured on CNN documentaries, [23] [26] The Doctors TV show, [70] 60 Minutes Australia , [71] and Dateline NBC , [72] among many other sources. An Article in the National Journal detailing the role of Several children have “uniquely Powerful advocates for medicinal pot across the country” Charlotte Described as the “first poster child for the end ….” [34] Her story led to her being white HAS as “the girl who is changing medical marijuana laws across America,” [6] as well as the “most famous example of medicinal hemp use”. [73]

Publicity and demand

When Charlotte was five years old, her story was featured in the August 11, 2013 CNN documentary “Weed”, hosted by Sanjay Gupta . [23] On November 24, 2013, Paige Figi was a guest on The Doctors TV show, where Charlotte’s story was told. [70] She was featured in Gupta’s March 11, 2014 CNN documentary “Weed 2: Cannabis Madness”. [26] The Doctors TV show again featured on Charlotte’s Web. The physicians called for a change of the Federal classification. [74] Sanjay Gupta has also expressed his support for Charlotte’s Web on the Doctors TV show.[75] On the October 17, 2014 episode of the ABC TV series The View , Paige Figi and Joel Stanley were interviewed by Whoopi Goldberg and Nicolle Wallace . [66]

Charlotte’s Web as a possible treatment for epilepsy and other conditions. [22] Colorado HAS Both legalized the medicinal and recreational use of marijuana, And Many relatives-have flocked there Suffering With Their children in search of Charlotte’s Web and other forms of medical marijuana. [76] In November 2013, CBS Denver reported that “[t] here is a growing community of 93 families with epileptic children using marijuana daily.” [24] In October 2014, Times noted the Stanley brothers had a waiting list of “more than 12,000 families.”[77] They have been termed “marijuana refugees”, [24] “part of a migration of families uprooting their lives in Colorado, where the medicinal use of marijuana is permitted … forced to flee states where cannabis is off limits . ” [78] [79] In November 2014, David Nutt MENTIONED Charlotte’s Web in the Royal Pharmaceutical Society ‘s Pharmaceutical Journal , Where he appealed for “the UK government [to] acts are evidence, Allowing the use of medicinal cannabis and Reducing barriers to its research. ” [80]

Families who say they have run out of pharmaceutical options to Colorado to access Charlotte’s Web. Actually, it is claimed that it is claimed. Amy Brooks-Kayal, vice president of the American Epilepsy Society, said that epileptic seizures may come into play. It is recommended that parents relocate to their country of origin rather than to Colorado. [81]

The product has been described as “the most famous brand of CBD oil”, [82] the “largest selling CBD oil in the country”, [83] and the “number one brand”, with 7% of the market. [84]


In November 2013, Josh Stanley said that Charlotte’s web was 0.5% THC and 17% CBD, [20] and that it “is safe and secure.” is illegal, federally, to take across state lines. ” [85] The legalities of selling the product to people who transport it is complicated, with difficulties for both the sellers and transporters. Regardless of state laws in Colorado and Utah which would allow the practice, it is still an offense. [86] [87] In September 2014, the content was measured at 0.3% THC. [5]


The relationship between the schedule and the status of cannabis in the United States and the lack of scientific research has been directly related. [88] The situation has been described as a “catch-22” paradox : “Marijuana is restricted because of its limitations.” [89] Sanjay Gupta has described the complex interaction between restrictive laws and lack of scientific research:

Gupta repeated throughout the evening that the “policy has outpaced the science.” The states, he said, “are moving forward without waiting for the science, and the issue is only compounded by the fact that the ‘policies and the laws we have in the [US] make it challenging for the science to get done.” [88]

Even though the Florida “Compassionate Medical Cannabis Act of 2014” (SB 1030) [43] Provides funding for research, the status of all cannabis products have illegal Schedule I drugs HAS limited the amount of research, with the University of Florida Refusing to do such research for fear of losing federal funding. [51] [90]

The research has been established in the documentary highlighted by Ed Maa, a specialist in epilepsy, stated: “This is not going away … I think it needs to be studied vigorously and very quickly. ” He hopes to “launch a clinical trial to study the pot and its potential.” [24] Physicians have called for more research to understand the potential benefits of medical marijuana; [8] Sharon Levy, director of the Adolescent Substance Abuse Program at Children’s Hospital Boston said:

“The AAP strongly supports these cannabinoid substances, which can be used to underestimate the effects of these drugs. [Purpose] the AAP does not support ‘medical marijuana’ laws as they circumvent regulations put in place to protect patients, and children are a particularly vulnerable population. ” [8]

Physicians have expressed both concern and concern about the sudden onset of medical marijuana and its research, both of which are “a scientist’s dream or a doctor’s nightmare.” They fear that some parents are too open to try anything, and that they may be disappointed. They are “alarmed by parallels to past miracle-cure manias later proved false …” and “… wary of the heightened placebo effect in treating children, when reports of progress depend on the view of parents.” [10] There is also danger that “the [legalization] movement also opens the way for bad medicine …According to Alan Shackelford, Charlotte Figi’s Physician: “We really do not know how it works … The cannabidiol seems to act as a neuro-stabilizer, but how? The research is tiny on this.” [91]

Orrin Devinsky , a neurologist at New York University’s Comprehensive Epilepsy Center, where he will conduct clinical trials on Epidiolex, [92] a high-CBD drug from GW Pharmaceuticals , expressed his sympathy for those who do not want to wait for research results [ 4]

I had a child who had failed, and they were having a terrible time, and they were having a lot of problems that were terribly disabling, I think it would be a very reasonable thing to try a high-CBD. cannabis product.

It also expresses the fact that the number of parents using the Charlotte’s Web extract will make it possible for children for the clinical trials, and that:

There are many more unknowns than known … the focus of the community-lay and scientific and governmental-should be on getting good information. That should be the real focus of what we need right now. [4]

The Epilepsy Foundation and Devilsky issued a joint statement calling for increased research and immediate access to medical marijuana, specifically naming Charlotte Figi’s case. Devinsky said:

We need to make a balanced decision about compassionate use. If I were Charlotte Figi’s parents and lived in Colorado I would have done exactly what they did. And as a doctor, I would gladly prescribe Marijuana products for many of my patients who would not be able to get medical treatment. with treatment-resistant epilepsy and their patients. [93]

Due to reports that some people have reported to Charlotte’s Web, an observational clinical trial was launched in September 2014 at the University of Colorado . [94] The study will run until February 2016, will focus on geneticdifferences between people who respond and do not respond, and attempt to determine if such genetic factors may be related to the success or failure of treatment. [95]